Question 1

Blimp-1 represses the expression of which of the following transcription factors?

Accepted Answer

A)  Blimp-1
B)  IRF-4
C)  Pax-5
D)  Bcl-6
E)  NF- ? BF) A) and B)
G) A) and C)

Question 2

What molecular events occur when a B cell encounters its cognate antigen for the first time? Describe the events occurring both inside and outside the cell membrane.

Accepted Answer

Outside of the cell, BCRs briefly spread...

Question 3

The follicular mantle zone consists primarily of which of the following?

Accepted Answer

A)  Follicular dendritic cells.
B)  Naïve IgD+ B cells that are not participating in the response against the antigen.
C)  TFH cells.
D)  Plasmacytoid dendritic cells.
E)  None of the answers are correct.F) A) and C)
G) A) and B)

Question 4

Why is it advantageous for most plasma cells to die by apoptosis at the end of an infection?

Accepted Answer

There are many reasons.First, it clears ...

Question 5

Which cells that are found within GC light zones are generally NOT found in the GC dark zones?

Accepted Answer

A)  Differentiating B cells.
B)  TFH cells.
C)  FDCs.
D)  Naïve IgD+ B cells that are not participating in the response to the antigen.
E)  None of the answers is correct.F) B) and D)
G) A) and B)

Question 6

Which of the following is or appears to be controlled by Blimp-1 during plasma cell differentiation?

Accepted Answer

A)  Exit from the cell cycle.
B)  Transitioning from membrane-bound to secreted IgM.
C)  Loss of MHC class II from the cell surface.
D)  All of the answers are correct.
E)  None of the answers are correct.F) A) and E)
G) A) and B)

Question 7

After encountering antigen, B cells express all of the following EXCEPT

Accepted Answer

A)  CCR7.
B)  CCL19.
C)  CXCR5.
D)  EBI2.
E)  All of the options are expressed.F) None of the above
G) B) and D)

Question 8

The B-cell coreceptor CD21 associates with which host molecule?

Accepted Answer

A)  C3d
B)  CD19
C)  The BCR
D)  Fc receptors
E)  None of the answers are correct.F) All of the above
G) B) and C)

Question 9

Which of the following is considered to be the "master regulator" of terminal plasma cell differentiation?

Accepted Answer

A)  Blimp-1
B)  IRF-4
C)  Pax-5
D)  Bcl-6
E)  NF- ? BF) C) and E)
G) A) and E)

Question 10

A knockout of which of the following genes results in the inability to form germinal centers?

Accepted Answer

A)  Blimp-1
B)  IRF-4
C)  Pax-5
D)  Bcl-6
E)  NF- ? BF) A) and B)
G) None of the above

Question 11

Which of the following do you expect would be actively functioning in a B cell that had migrated to a germinal center?

Accepted Answer

A)  RAG1
B)  Artemis
C)  AID
D)  Ku70
E)  None of the answers are correct.F) B) and C)
G) All of the above

Question 12

Which of the following factors is thought to induce expression of Blimp-1?

Accepted Answer

A)  IRF-4
B)  Pax-5
C)  Bcl-6
D)  NF- ? B
E)  None of the answers are correct.F) A) and B)
G) A) and C)

Question 13

Which of the following statements are TRUE about ?? T cells and B-1 B cells?

Accepted Answer

A)  Both can self-renew in the periphery and do not need to be replenished from primary lymphoid tissues.
B)  Both have identical lymphocyte receptors to one another.
C)  Both respond to their antigens via high-affinity receptor responses.
D)  All of the answers are true.
E)  None of the answers are true.F) B) and D)
G) C) and D)

Question 14

What is the MOST common type of activated B cell? What are three other types and what kind of antigens do they typically recognize?

Accepted Answer

Most of our circulating B cells are the ...

Question 15

What is AID, what does it do, and what two B cell processes cannot happen without it?

Accepted Answer

This is an odd combination because IgM i...

Question 16

Which of the following statements is TRUE about B-1 B cells and MZB cells?

Accepted Answer

A)  Both are self-renewing in the periphery, not requiring replacement from bone marrow.
B)  Both can respond to TI antigen.
C)  Both do not undergo SHM.
D)  Both are self-renewing in the periphery, not requiring replacement from bone marrow, and can respond to TI antigen.
E)  None of the answers are true.F) A) and B)
G) All of the above

Question 17

Which factors on the surfaces of B cells and T cells, through their interaction, are required to allow germinal center formation to occur?

Accepted Answer

A)  CD40 and CD40L.
B)  Fas and FasL.
C)  CD28 and CD80/86.
D)  TCR and MHC class II.
E)  None of the answers are correct.F) B) and C)
G) A) and C)

Question 18

AID converts cytosine into which of the following bases?

Accepted Answer

A)  Adenine
B)  Thymine
C)  Deoxyuridine
D)  Guanine
E)  None of the answers are correct.F) C) and D)
G) C) and E)

Question 19

To which compartment in the body can long-lived plasma cells potentially be retained for the lifetime of the individual?

Accepted Answer

A)  Medullary cords of the lymph node.
B)  Germinal center.
C)  Bone marrow.
D)  Red pulp of spleen.
E)  None of the answers are correct.F) C) and D)
G) B) and C)

Question 20

Which of the following does NOT occur shortly following oligomerization of the BCR upon antigen binding?

Accepted Answer

A)  Movement of the BCR complex into areas of the membrane called "lipid rafts".
B)  Positioning of Ig. ? and g ? to allow for phosphorylation of their ITAM motifs
C)  Positioning of CD3 to allow for phosphorylation of its ITAM motifs.
D)  Formation of clathrin-coated pits around BCR complex.
E)  All of the answers occur.F) C) and D)
G) A) and D)

Exam 11: B-Cell Activation, Differentiation, and Memory

After encountering antigen, B cells express all of the following EXCEPT

Correct AnswerverifiedShow Answer

What is AID, what does it do, and what two B cell processes cannot happen without it?

Correct AnswerverifiedThis is an odd combination because IgM i...View AnswerShow Answer

The follicular mantle zone consists primarily of which of the following?

Correct AnswerverifiedShow Answer

What molecular events occur when a B cell encounters its cognate antigen for the first time? Describe the events occurring both inside and outside the cell membrane.

Correct AnswerverifiedOutside of the cell, BCRs briefly spread...View AnswerShow Answer

What is the MOST common type of activated B cell? What are three other types and what kind of antigens do they typically recognize?

Correct AnswerverifiedMost of our circulating B cells are the ...View AnswerShow Answer

To which compartment in the body can long-lived plasma cells potentially be retained for the lifetime of the individual?

Correct AnswerverifiedShow Answer

Which of the following is or appears to be controlled by Blimp-1 during plasma cell differentiation?

Correct AnswerverifiedShow Answer

Which cells that are found within GC light zones are generally NOT found in the GC dark zones?

Correct AnswerverifiedShow Answer

Which of the following do you expect would be actively functioning in a B cell that had migrated to a germinal center?

Correct AnswerverifiedShow Answer

The B-cell coreceptor CD21 associates with which host molecule?

Correct AnswerverifiedShow Answer

A knockout of which of the following genes results in the inability to form germinal centers?

Correct AnswerverifiedShow Answer

Which of the following statements is TRUE about B-1 B cells and MZB cells?

Correct AnswerverifiedShow Answer

Which of the following factors is thought to induce expression of Blimp-1?

Correct AnswerverifiedShow Answer

AID converts cytosine into which of the following bases?

Correct AnswerverifiedShow Answer

Which factors on the surfaces of B cells and T cells, through their interaction, are required to allow germinal center formation to occur?

Correct AnswerverifiedShow Answer

Which of the following statements are TRUE about ?? T cells and B-1 B cells?

Correct AnswerverifiedShow Answer

Why is it advantageous for most plasma cells to die by apoptosis at the end of an infection?

Correct AnswerverifiedThere are many reasons.First, it clears ...View AnswerShow Answer

Which of the following does NOT occur shortly following oligomerization of the BCR upon antigen binding?

Correct AnswerverifiedShow Answer

Blimp-1 represses the expression of which of the following transcription factors?

Correct AnswerverifiedShow Answer

Which of the following is considered to be the "master regulator" of terminal plasma cell differentiation?

Correct AnswerverifiedShow Answer

Correct Answer
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Correct Answer
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This is an odd combination because IgM i...
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Correct Answer
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Correct Answer
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Outside of the cell, BCRs briefly spread...
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Correct Answer
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Most of our circulating B cells are the ...
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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Correct Answer
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There are many reasons.First, it clears ...
View Answer

Correct Answer
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Correct Answer
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