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Which of the following statements is true?


A) The hydrogen bonding of cytosine to guanine is an example of complementary base pairing.
B) In DNA, adenine always base pairs with guanine, and cytosine always base pairs with thymine.
C) Each of the four nucleotides in a DNA molecule has the same nitrogen-containing base.
D) When adenine base pairs with thymine, they are linked by three hydrogen bonds.
E) None of these statements are true.

F) A) and B)
G) D) and E)

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Which of the following statements is NOT true concerning the results of Fred Griffith's experiments?


A) Mice injected with smooth (S) bacteria die.
B) Mice injected with heat-killed, smooth bacteria die.
C) Mice injected with heat-killed, smooth bacteria and live, rough (R) bacteria die.
D) Mice injected with rough bacteria live.
E) The rough bacteria received genetic material from the smooth bacteria.

F) A) and D)
G) B) and E)

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DNA replication is


A) redundant.
B) semiconservative.
C) progressive.
D) conservative.
E) repetitive.

F) C) and E)
G) A) and D)

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If all of the hydrogen bonds in a DNA molecule were to break,


A) the nucleotide base pairs would separate from each other.
B) base pairing would not be affected.
C) the phosphate groups would separate from the deoxyribose sugars.
D) the deoxyribose sugars would separate from the nitrogen-containing bases.
E) the molecule would unwind, but the two strands would stay together.

F) A) and D)
G) A) and C)

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In the spiral staircase model of DNA, the rungs are


A) deoxyribose sugars.
B) hydrogen bonds.
C) nucleotide base pairs.
D) phosphate groups.
E) composed of all of these.

F) A) and C)
G) A) and B)

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C

The commercial cloning of pets and livestock is already being performed.The example in the introduction of your book was of a cloned


A) cat.
B) bull.
C) pig.
D) elk.
E) dog.

F) C) and D)
G) A) and D)

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Which scientist(s) identified the transforming substance involved in changing rough (R) bacteria to smooth (S) ?


A) Avery and McCarty
B) Griffith
C) Chargaff
D) Hershey and Chase
E) Pauling

F) A) and E)
G) A) and B)

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Which scientist(s) discovered the basis for the base-pair rule, which states that the amounts of adenine and thymine match, as do the amounts of cytosine and guanine?


A) Avery
B) Griffith
C) Chargaff
D) Hershey and Chase
E) Pauling

F) A) and B)
G) None of the above

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The major challenge in using adult DNA in the cloning process is


A) purifying the DNA.
B) inserting the DNA into cells.
C) reprogramming it to function like the DNA of an egg
D) turning off unnecessary genes.
E) determining what DNA is best to use.

F) B) and E)
G) A) and D)

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Rosalind Franklin's research contribution was essential in


A) establishing the chemical composition of DNA.
B) establishing the principle of base pairing.
C) establishing the principal dimensions of the DNA molecule.
D) determining the sequence of nucleotides in DNA.
E) determining the covalent bonding angles within DNA nucleotides.

F) A) and B)
G) None of the above

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James Watson and Francis Crick


A) were both English researchers working at Cambridge University.
B) performed elegant experiments in DNA chemistry.
C) constructed an accurate model of the DNA molecule illustrating its structural simplicity.
D) performed experiments that convinced scientists that DNA is a double-stranded molecule.
E) did all of these

F) All of the above
G) A) and B)

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C

DNA polymerase assembles new strands


A) in a 5' to 3' direction only.
B) in a 5' to 3' direction building one strand and a 3' to 5' direction building the other stand.
C) in a 5' to 3' direction building the first half of a strand and a 3' to 5' direction building the second half of a strand.
D) in a 3' to 5' direction building the first half of a strand and a 5' to 3' direction building the second half of a strand.
E) in a 3' to 5' direction on the "old" 3' to 5' strand.

F) A) and D)
G) A) and C)

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If adenine bonds with guanine, and thymine bonds with cytosine, the DNA molecule would


A) be constricted along its entire length.
B) bulge where cytosine bonds with thymine.
C) constrict where adenine bonds with guanine.
D) partially constrict and partially bulge along its length.
E) be highly reactive.

F) B) and E)
G) B) and C)

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Johann Miescher worked with __________ cells.


A) sperm
B) red blood
C) nerve
D) muscle
E) none of these

F) B) and C)
G) All of the above

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Rosalind Franklin used which technique to determine many of the physical characteristics of DNA?


A) transformation
B) transmission electron microscopy
C) density-gradient centrifugation
D) X-ray diffraction
E) all of these

F) A) and D)
G) A) and C)

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Who was NOT involved in working out the structure of DNA?


A) Avery
B) Watson
C) Wilkins
D) Franklin
E) Chargaff

F) A) and B)
G) A) and C)

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Thealpha helix was described by


A) Pauling.
B) Hershey and Chase.
C) Griffith.
D) Watson and Crick.
E) Avery.

F) B) and E)
G) D) and E)

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A

Bacteriophages are


A) large bacteria.
B) pathogenic bacteria.
C) viruses that infect bacteria.
D) virus-eating bacteria.
E) viruses that infect eukaryotic cells.

F) C) and D)
G) B) and D)

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Fred Griffith's experiments with two strains of Streptococcus pneumoniae


A) resulted in a vaccine against bacterial pneumonia.
B) demonstrated that rough (R) bacteria cause pneumonia.
C) provided evidence that genetic material from one bacterial strain can be transferred to that of another strain.
D) demonstrated that mice can transform harmless bacteria into pathogenic bacteria.
E) demonstrated that a harmless, smooth bacterial strain can be transformed into a lethal, rough bacterial strain.

F) C) and E)
G) A) and D)

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Dolly the cloned sheep was conceived by inserting


A) a nucleus from an egg cell into an unfertilized egg.
B) a nucleus from a body cell into an unfertilized egg.
C) a nucleus from a sperm cell into an unfertilized egg.
D) two nuclei from body cells into an enucleated egg cell.
E) a nucleus from a body cell into an enucleated egg cell.

F) None of the above
G) A) and C)

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